Innovative in silico approaches to address avian flu using grid technology

The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology.Comment: 7 pages, submitted to Infectious Disorders - Drug Target

Grid-enabled sentinel network for cancer surveillance

International audienc

Development of a metamodel for medical database management on a grid network: Application to Health Watch and epidemiology for cancer and perinatal health.

International audienceCentralized management of patient data is no more a viable solution. In many countries, patient identification restrictions due to privacy laws implies developing thorough mechanism to avoid duplicates and information loss. In this paper we present a work in progress dealing with a grid distributed medical data base. GPU based identification algorithms for disease surveillance, medical data exchange and epidemiological analyses

Eight Years Using Grids for Life Sciences

PCS